since there are well known Problems with the Activation Plugin on CS6 i have perhaps some Informations for you,
cause i run in this Issue the last days. The Problem on my Mac (OSX 10.7.5, Suitcase 15.0.5, Photoshop CS6 13,1,2) are that on some larger PSD Files with many Smart Objects the file could only be saved and opened with very long time deferrals
and also the apple rotation wheel. I have made some test to solve the problem. First of all checked the preferences as many others in the internet. But this not really solve the problem. It happen again and again. Today i test it to rasterize all Smart Objects and save it again. And see fast starts and fast save. Then i take the same document with smart objects and deactivate the Font Activation Plugin. And also fast open and fast save. So It seems that the font activation plugin has some great problems in conjunction with Smart Objects. To solve actual the problem i find a workaround in the global font activation for Photoshop and put it in the Preferences list. Curiously this work also pretty good. Further fast save and open. So my conclusion is that the plugin has a big problem with smart objects.
Hope this will help and you will find a fast solution, also of cause this is not a workaround for the Universal Type Server 3 and Clients which dont have these global activation. There the same problems occurs with save and open.